L‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease
Identifieur interne : 001610 ( Main/Exploration ); précédent : 001609; suivant : 001611L‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease
Auteurs : Kim Tieu [États-Unis] ; Celine Perier [États-Unis] ; Miquel Vila [États-Unis] ; Casper Caspersen [États-Unis] ; Hui-Ping Zhang [République populaire de Chine] ; Peter Teismann [Allemagne] ; Vernice Jackson-Lewis [États-Unis] ; David M. Stern [États-Unis] ; Shi Du Yan [États-Unis] ; Serge Przedborski [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2004-07.
Abstract
The neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) impairs mitochondrial respiration and damages dopaminergic neurons as seen in Parkinson's disease (PD). Here, we report that L‐3‐hydroxyacyl‐CoA dehydrogenase type II/amyloid binding alcohol dehydrogenase (HADH II/ABAD), a mitochondrial oxidoreductase enzyme involved in neuronal survival, is downregulated in PD patients and in MPTP‐intoxicated mice. We also show that transgenic mice with increased expression of human HADH II/ABAD are significantly more resistant to MPTP than their wild‐type littermates. This effect appears to be mediated by overexpression of HADH II/ABAD mitigating MPTP‐induced impairment of oxidative phosphorylation and ATP production. This study demonstrates that HADH II/ABAD modulates MPTP neurotoxicity and suggests that HADH II/ABAD mimetics may provide protective benefit in the treatment of PD. Ann Neurol 2004;56:51–60
Url:
DOI: 10.1002/ana.20133
Affiliations:
- Allemagne, République populaire de Chine, États-Unis
- Bade-Wurtemberg, District de Tübingen, Géorgie (États-Unis), État de New York
- Tübingen
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">L‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease</title><author><name sortKey="Tieu, Kim" sort="Tieu, Kim" uniqKey="Tieu K" first="Kim" last="Tieu">Kim Tieu</name></author><author><name sortKey="Perier, Celine" sort="Perier, Celine" uniqKey="Perier C" first="Celine" last="Perier">Celine Perier</name></author><author><name sortKey="Vila, Miquel" sort="Vila, Miquel" uniqKey="Vila M" first="Miquel" last="Vila">Miquel Vila</name></author><author><name sortKey="Caspersen, Casper" sort="Caspersen, Casper" uniqKey="Caspersen C" first="Casper" last="Caspersen">Casper Caspersen</name></author><author><name sortKey="Zhang, Hui Ing" sort="Zhang, Hui Ing" uniqKey="Zhang H" first="Hui-Ping" last="Zhang">Hui-Ping Zhang</name></author><author><name sortKey="Teismann, Peter" sort="Teismann, Peter" uniqKey="Teismann P" first="Peter" last="Teismann">Peter Teismann</name></author><author><name sortKey="Jackson Ewis, Vernice" sort="Jackson Ewis, Vernice" uniqKey="Jackson Ewis V" first="Vernice" last="Jackson-Lewis">Vernice Jackson-Lewis</name></author><author><name sortKey="Stern, David M" sort="Stern, David M" uniqKey="Stern D" first="David M." last="Stern">David M. Stern</name></author><author><name sortKey="Yan, Shi Du" sort="Yan, Shi Du" uniqKey="Yan S" first="Shi Du" last="Yan">Shi Du Yan</name></author><author><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9BA4829E8CBF4A15B10C3FEFAFF8002681FF7D52</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/ana.20133</idno><idno type="url">https://api.istex.fr/document/9BA4829E8CBF4A15B10C3FEFAFF8002681FF7D52/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">003045</idno><idno type="wicri:Area/Main/Curation">002C51</idno><idno type="wicri:Area/Main/Exploration">001610</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">L‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease</title><author><name sortKey="Tieu, Kim" sort="Tieu, Kim" uniqKey="Tieu K" first="Kim" last="Tieu">Kim Tieu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Perier, Celine" sort="Perier, Celine" uniqKey="Perier C" first="Celine" last="Perier">Celine Perier</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Vila, Miquel" sort="Vila, Miquel" uniqKey="Vila M" first="Miquel" last="Vila">Miquel Vila</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Caspersen, Casper" sort="Caspersen, Casper" uniqKey="Caspersen C" first="Casper" last="Caspersen">Casper Caspersen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Surgery, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Hui Ing" sort="Zhang, Hui Ing" uniqKey="Zhang H" first="Hui-Ping" last="Zhang">Hui-Ping Zhang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian</wicri:regionArea><wicri:noRegion>Fujian</wicri:noRegion></affiliation></author><author><name sortKey="Teismann, Peter" sort="Teismann, Peter" uniqKey="Teismann P" first="Peter" last="Teismann">Peter Teismann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of General Neurology, Center of Neurology and Hertie Institute for Clinical Brain Research University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Jackson Ewis, Vernice" sort="Jackson Ewis, Vernice" uniqKey="Jackson Ewis V" first="Vernice" last="Jackson-Lewis">Vernice Jackson-Lewis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Stern, David M" sort="Stern, David M" uniqKey="Stern D" first="David M." last="Stern">David M. Stern</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>School of Medicine, Medical College of Georgia, Augusta</wicri:cityArea></affiliation></author><author><name sortKey="Yan, Shi Du" sort="Yan, Shi Du" uniqKey="Yan S" first="Shi Du" last="Yan">Shi Du Yan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Surgery, Columbia University, New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Columbia University, New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Taub Institute for Research on Alzheimer disease and the Aging Brain, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Columbia University, New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Columbia University, New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurobiology and Behavior, Columbia University, New York</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-07">2004-07</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="51">51</biblScope><biblScope unit="page" to="60">60</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">9BA4829E8CBF4A15B10C3FEFAFF8002681FF7D52</idno><idno type="DOI">10.1002/ana.20133</idno><idno type="ArticleID">ANA20133</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) impairs mitochondrial respiration and damages dopaminergic neurons as seen in Parkinson's disease (PD). Here, we report that L‐3‐hydroxyacyl‐CoA dehydrogenase type II/amyloid binding alcohol dehydrogenase (HADH II/ABAD), a mitochondrial oxidoreductase enzyme involved in neuronal survival, is downregulated in PD patients and in MPTP‐intoxicated mice. We also show that transgenic mice with increased expression of human HADH II/ABAD are significantly more resistant to MPTP than their wild‐type littermates. This effect appears to be mediated by overexpression of HADH II/ABAD mitigating MPTP‐induced impairment of oxidative phosphorylation and ATP production. This study demonstrates that HADH II/ABAD modulates MPTP neurotoxicity and suggests that HADH II/ABAD mimetics may provide protective benefit in the treatment of PD. Ann Neurol 2004;56:51–60</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Géorgie (États-Unis)</li><li>État de New York</li></region><settlement><li>Tübingen</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Tieu, Kim" sort="Tieu, Kim" uniqKey="Tieu K" first="Kim" last="Tieu">Kim Tieu</name></region><name sortKey="Caspersen, Casper" sort="Caspersen, Casper" uniqKey="Caspersen C" first="Casper" last="Caspersen">Casper Caspersen</name><name sortKey="Jackson Ewis, Vernice" sort="Jackson Ewis, Vernice" uniqKey="Jackson Ewis V" first="Vernice" last="Jackson-Lewis">Vernice Jackson-Lewis</name><name sortKey="Perier, Celine" sort="Perier, Celine" uniqKey="Perier C" first="Celine" last="Perier">Celine Perier</name><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name><name sortKey="Stern, David M" sort="Stern, David M" uniqKey="Stern D" first="David M." last="Stern">David M. Stern</name><name sortKey="Vila, Miquel" sort="Vila, Miquel" uniqKey="Vila M" first="Miquel" last="Vila">Miquel Vila</name><name sortKey="Yan, Shi Du" sort="Yan, Shi Du" uniqKey="Yan S" first="Shi Du" last="Yan">Shi Du Yan</name><name sortKey="Yan, Shi Du" sort="Yan, Shi Du" uniqKey="Yan S" first="Shi Du" last="Yan">Shi Du Yan</name><name sortKey="Yan, Shi Du" sort="Yan, Shi Du" uniqKey="Yan S" first="Shi Du" last="Yan">Shi Du Yan</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Hui Ing" sort="Zhang, Hui Ing" uniqKey="Zhang H" first="Hui-Ping" last="Zhang">Hui-Ping Zhang</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Teismann, Peter" sort="Teismann, Peter" uniqKey="Teismann P" first="Peter" last="Teismann">Peter Teismann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001610 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001610 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9BA4829E8CBF4A15B10C3FEFAFF8002681FF7D52
|texte= L‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |